Project Description

Medical Grade Beta-tricalcium Phosphate

As commonly used biomaterial, medical grade Beta-tricalcium or β-TCP has great biological compatibility. Once implanted into human body, the degradation will occur under physiological conditions and provide rich Ca and P for the formation of new bone.

Medical beta TCP from EPRUI can be used as ideal material for bone filling, bone repair, bone substitutes and bone graft.

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medical grade tricalcium phosphate

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Beta TCP Product List

ItemAverage Particle SizePurity
EPRUI-BTCP01200nm>98%
EPRUI-BTCP025um>98%
EPRUI-BTCP0310um>98%
EPRUI-BTCP0420um>98%
EPRUI-BTCP0555um>98%
EPRUI-BTCP0675um>98%
EPRUI-BTCP07100um>98%
EPRUI-BTCP08150um>98%
EPRUI-BTCP09200um>98%

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Buying Guide of Medical Grade Beta TCP

Medical grade Beta-tricalcium phosphate is a kind of amorphous white powder. It is odorless and stable in air which is almost insoluble in cold water. Beta-tricalcium phosphate is soluble in dilute hydrochloric acid and nitric acid. It is insoluble in ethanol and acetone.

Medical grade Beta-tricalcium or β-TCP has great biological compatibility. Once implanted into human body, the degradation will occur under physiological conditions and provide rich Ca and P for the formation of new bone. EPRUI beta TCP can be used as ideal material for bone filling, bone repair and bone graft.

1. What is physical property of medical Beta TCP?

Chemical nameBeta Tricalcium Phosphate, β-TCP, β-Tricalcium Phosphate
AppearanceWhite powder or granules
OdorOdorless
MorphologyHexagonal
GradeMedical Grade
StandardYY/T 0683-2008; ASTM F 1088-04a
Molecular Weight310.18
FormulaCa3 (PO4)2
Cas No.7758-87-4
Density3.12 g/cm3
Melting Point1670 ℃
Refractive index1.626
SolubilityIt is soluble in dilute hydrochloric acid and nitric acid while insoluble in ethanol, acetone and cold water.

Molecular Structure

beta tcp molecular structure

2. What are applications of medical Beta TCP?

  • Degradable bone cement
  • Synthetic bone substitute materials
  • Artificial bone scaffold
  • Biocompatible bone nail,bone screw, bone plate
  • 3D bioprinting materials
  • Drug release and drug loading

3. Why medical beta TCP can be good bone substitute materials?

Tricalcium phosphate has similar composition (Ca:P=1.5) to the inorganic components in biological bone. Therefore, it has good biocompatibility, bioactivity and biodegradability. Medical grade beta TCP, as biomaterials of bone substitutes, has been given close attention in the biomedical industry since 1991. It is non-toxic, non-local irritant, does not cause hemolysis or coagulation, and does not cause mutation or cancer. It is biodegradable or bioabsorbable bioactive material with good biocompatibility, bone conduction and even osteoinduction function.

What’s more, the degraded Ca and P enter the living circulatory system to form new bone, so medical beta TCP can be used as ideal material for bone filling, bone repair and bone graft.

When medical grade beta TCP is implanted into human body, it can be degraded and absorbed in body fluids. Calcium and phosphorus are absorbed by the body fluid and enter the human circulatory system. After a certain period of time, the medical β-TCP implanted in the body gradually dissolves and disappears, forming new bones.

A large number of experimental studies have proven that medical grade beta tricalcium phosphate has no adverse effects on bone marrow hematopoietic function, no rejection reactions, no acute toxicity reactions, and no allergies. Therefore, medical grade β-TCP can be widely used in joint and spine fusion, limb trauma, oral and maxillofacial surgery, cardiovascular surgery, and filling of periodontal cavity. With continuous research on medical β-TCP, its application forms have also diversified, and it has shown better performance in clinical medicine. Besides, medical β-TCP can be used to prepare sintered bioceramics, and can also be used as a carrier for drugs such as antibiotics and growth factors.

In addition, β-TCP is also widely used clinically in hip and knee joints, artificial tooth roots, dental palate elevation and reinforcement, maxillofacial and middle ear ossicular reconstruction.

4. What are differences between medical HAP and beta TCP?

Both medical HAP and beta TCP can serve as bone substitutes that work by providing a scaffold for vascular ingrowth, which then leads to bone apposition. Medical HAP is superior in promotion of early bone regeneration when compared with medical beta TCP while medical beta TCP is more biodegradable.

5. What are differences between medical beta TCP and alpha TCP?

There are two types of TCP crystal phase structure: high temperature type alpha phase and low temperature type beta phase. The crystal of alpha phase is monoclinic and the density is 2.869 / cm3, and the morphology of beta phase is hexahedron and its density is 3.079 / cm3. The phase transition temperature of β-TCP to alpha-TCP is 1120 ~ 1160 ℃.

At present, the research and application of bioactive ceramic materials generally goes toβmedical beta-TCP instead of alpha TCP.

The main reasons are as follows:

① The solubility of a-TCP is too large, and it degrades too quickly after being implanted into the human body, resulting in the artificial bone material not functioning well.
② When the temperature rises and the TCP changes from beta phase to alpha phase, the volume will increase, which will cause the ceramic to expand and crack, thereby reducing its mechanical properties

6. Why choose medical beta TCP from EPRUI?

  • EPRUI supplies medical TCP meet Chinese pharmaceutical standards YY / T 0683-2008 which is corresponding to International Standard ASTM F 1088-04a.
  • The lab to make medical grade HA and TCP products is built according to GMP requirement.
  • EPRUI provides customization service and professional technical support for your research products.
  • EPRUI has the ability to provide medical grade beta TCP and HAP products in large scale. Therefore, bulk price can be offered based on order quantity.
  • Our medical grade beta tricalcium phosphate meet the Chinese pharmaceutical standards YY / T 0683-2008 which is corresponding to International Standard ASTM F 1088-04a: Surgical implants used beta tricalcium phosphate.
  • Our lab is built according to GMP requirement.

7. How to order

Please send e-mail to: [email protected] or call us by 86-21-64192663 for products inquires.

For detailed steps, please visit: How to Buy

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