Medical Grade PLLA Microspheres

Poly-L-Lactic Acid (abbreviated as PLLA), also known as L-polylactic acid, is a high-crystallinity, biosafe degradable medical polymer raw material presented as white or off-white solid powder or granules depends on particle morphology and particle size. Its unique regular L-molecular structure delivers stable crystalline properties, outstanding mechanical performance and exceptional processing plasticity.

As a benchmark degradable raw material across global biomedicine, anti-aging aesthetic medicine, medical consumables and cosmetics, PLLA can be fabricated into PLLA microspheres, microcapsules, films, fibers, scaffolds and other forms to fit diversified high-end scenarios including clinical treatment, targeted drug delivery, long-term sustained release, aesthetic filling and functional skincare. Its biosafety and application compatibility have been long verified by global markets, making it a core mainstream material in absorbable biomaterials.

Superior Biocompatibility: Suitable for medical and aesthetic applications

Our medical grade PLLA microspheres comply fully with international and domestic testing standards for medical biomaterials. It is impurity-free medical grade raw materials and exhibits high compatibility within skin soft tissues and human hard/soft tissues after implantation or contact. It causes no rejection, sensitization, inflammatory irritation or foreign body nodule formation,which is suitable for superficial aesthetic filling, subcutaneous implantation, skincare and in-vivo implant devices, it boasts a solid safety foundation for long-term human contact and internal implantation.

100% Biodegradable, Zero Residue & No Burden on the Human Bodies

PLLA features its 100% complete, gradual, stable and natural biodegradation in human bodies and biological environments. Its final degradation product is lactic acid, a substance naturally present in the human body. Lactic acid directly participates in the tricarboxylic acid cycle, further breaking down into carbon dioxide and water that are fully excreted via respiration, sweat, urine and other metabolic pathways. No harmful substances are released during the whole process, leaving no internal residues or metabolic burdens. It is safe for superficial aesthetic injection, skincare, in-vivo medical implantation and drug carrier applications.

Precisely Controllable Degradation Rate for Full-Scenario Adaptation

By fine-tuning core parameters including molecular weight, crystallinity and particle size, we can customize degradation cycles flexibly to match diverse application demands. Multiple degradation modes are available: rapid short-term degradation, steady medium-to-long-term degradation, and long-term sustained release degradation. This perfectly aligns material degradation rhythm with tissue regeneration and drug release timelines for long-acting sustained-release drugs, targeted delivery, collagen regeneration aesthetics, wound repair and orthopedic tissue healing, eliminating premature material failure or persistent residual issues.

Perfect Spherical Morphology and Precisely  controllable particle size distribution

EPRUI Biotech is able to provide 20-40um(EPRUI-PLLA01-20-40u) and 30-60um(EPRUI-PLLA01-30-60u) medical grade PLLA microspheres with perfect spherical morphology and precisely controllable particle size distribution. SEM Microscopies are available for evaluation.

Superior Mechanical Properties & Exceptional Molding Plasticity

Supported by regular L-molecular chains and high-crystallinity structure, PLLA combines long-lasting mechanical support and strong plasticity. It delivers robust supporting stability for rigid medical applications such as orthopedic implants and soft tissue supports; meanwhile, it can be processed into ultra-fine microspheres, films, fibers and other refined forms to fit delicate scenarios including aesthetic filling, cosmetic additives and drug carrier manufacturing, meeting customized production demands for all medical, aesthetic and skincare products.

Currently 20-40um(EPRUI-PLLA01-20-40u) and 30-60um(EPRUI-PLLA01-30-60u) PLLA microspheres are available from stock.

PLLA microspheres smaller than 20 μm carry the risk of being phagocytosed by immune cells (macrophages), which can render them unable to stimulate collagen regeneration and thus lead to unsatisfactory aesthetic outcomes.

From a clinical efficacy perspective, larger PLLA microspheres offer a greater surface area, allowing more fibroblasts to adhere. This, in turn, enhances collagen regeneration, leading to a larger volume of extracellular matrix (ECM) and consequently more pronounced aesthetic effects. However, larger particle sizes (especially >80 μm) are associated with increased side effects, particularly a higher incidence of nodules. Moreover, microspheres larger than 100 μm tend to clog needles during injection, compromising the clinician’s handling experience.

Therefore, for those seeking longerlasting aesthetic results, PLLA microspheres with slower degradation and a more extended collagenstimulation cycle are recommended. Specifically, we suggest:

EPRUI-PLLA01-30-60u (30–60 μm): suitable for deep volumetric filling and contour shaping, such as in the temples, cheeks, and jawline, where greater structural support is required.

EPRUI-PLLA01-20-40u (20–40 μm): with smaller particles and a more homogeneous suspension, this grade is ideal for superficial, finedetail injections—for example, in the periorbital and perioral areas with thinner skin, or for treating fine lines and enlarged pores.

EPRUI Biotech provides deep processing services for various dermal filler use raw materials per client requirements, including Poly-L-Lactic Acid (PLLA), 25-45um Hydroxyapatite (CaHA), PMMA,PDLLA, PCL and PLCL microspheres. All raw materials are produced in a Class 100,000 clean workshop and undergo radiation sterilization to guarantee hygiene and safety.

Please send e-mail to: sales@epruibiotech.com  for products inquires.